Professional baseball in Ciudad Obregón dates back to 1947, when the first club was established, nicknamed Arroceros (Rice Growers). In 1958 they changed its nickname to Rojos (Reds) and in 1964 to Trigueros (Wheat Growers).
The Yaquis de Obregon were founded in 1970 and played their first game on October 8, 1970 at the Tomás Oroz Gaytan Stadium.
The Yaquis have been champions of the league six times. The first one was in the 1965–1966 season with Mexican Manuel Magallón as coach. The next two titles were on the 1972–1973 season under Dave Garcia from the United States and the 1980–1981 season under Lee Sigman. On 27 January 2008 Yaquis won their fourth championship, defeating Venados de Mazatlán four games to one, with Mexican Homar Rojas as manager.
Managed by Domincan Eddie Díaz, the Yaquis won the 2010-11 championship, defeating Algodoneros de Guasave four games to three, and went on to win the 2011 Caribbean Series contested in Mayagüez, Puerto Rico. The Yaquis won a second and third consecutive title after winning the 2011-2012 and 2012-2013 championships under Díaz. Later, they went on to win the 2013 Caribbean Series. The 2013 Caribbean Series was the first to feature a final game after a Round-robin tournament. The final game lasted 18 inning ending at 2 am local time. The Yaquis are the first team in the Liga Mexicana del Pacífico to win three championships in a row.
