Five-time Grand Slam champions Krejčíková and Siniaková are the third highest seeded pair at the tournament. During the current season, the Czechs already managed to dominate the Australian Open and Wimbledon. In New York, they reached the semifinals the furthest in 2018.
The winners will face the better pair of Flipkensová, Sorribesová Tormová – Melicharová-Martinezová, Perezová in the semi-finals.