SportsLine AI has projected game outcomes and point spreads across the entire NFL slate as teams reach Week 10.
SportsLine AI, developed using data science techniques by the SportsLine data science team, has evaluated odds and generated predictions for every matchup on the upcoming schedule. The model forecasts a 38-28 victory for the Buffalo Bills over the New York Jets.
The Bills enter the contest leading the AFC East after placing second in the division a year ago. Buffalo is led by quarterback Josh Allen, who earned the NFL MVP award in 2024.
The Jets hold a 2-7 record and sit third in the division. Buffalo has won each of the past five meetings between the two franchises, which includes a pair of victories by margins of 20 points or more during the 2025 season.
The model evaluations draw on historical team data paired with quantitative defensive matchup scores assigned out of 100. The system updates using newly available statistics to identify discrepancies across betting markets.
Divisional Matchups Shape Week 10 Schedule
Four teams are on byes for Week 10: the Chicago Bears, Denver Broncos, Tampa Bay Buccaneers, and Philadelphia Eagles. The slate features several divisional pairings, including the Panthers against the Saints, the Jaguars facing the Titans, and the Vikings playing the Packers.
Additional conference games on the Sunday schedule feature the Texans meeting the Browns, the Dolphins playing the Colts, and the 49ers facing the Cowboys. The prime-time schedule concludes with the Steelers visiting the Bengals on Sunday Night Football.
The Jacksonville Jaguars enter their divisional matchup against the Titans with a 6-2 record. They boast the second-ranked scoring defense allowing 15.4 points per game and the fourth-ranked scoring offense putting up 28.6 points per game.
New Jaguars safety Jessie Bates III and defensive tackles Davon Godchaux and Jordan Davis will face the Titans in their first game for Jacksonville.
The slate also includes the Kansas City Chiefs facing the Atlanta Falcons on the road. Patrick Mahomes practiced fully after dealing with an elbow injury.
The slate also includes the Cincinnati Bengals meeting the Pittsburgh Steelers.
Earlier coverage: NFL Week 10 Schedule: 14 Matchups Including Munich Game and Vikings-Packers Clash
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