With his 400th individual victory in a Grand Slam tournament, Novak Djokovic moved into the round of 16 with a 3-0 win against Botic van de Zandschulp on Saturday, despite minor problems and a temporary medical timeout. The Serbian superstar benefited from the fact that Jakub Mensik had to give up without a fight, so that Djoker made it to the quarter-finals with a bye. That the 38-year-old long-running favorite now regenerate for a full three days ensures that we clearly favor Lorenzo Musetti against Novak Djokovic as to whether the ten-time Australian Open winner will advance.
Get a €20 free bet for the Austrialian Open at Interwetten & win VIP tickets to the Boss Open 2026

T&Cs apply | 18+
This is how it works
- Log in
Click on register now or register here
- Choose IW voucher as payment method
Enter the code AO20 and receive a €20 free bet immediately.
- Place a bet
Bet on the favorite at the Australian Open.
- Participate in the competition
All people who redeem the free bet automatically take part in the competition for 1×2 VIP trip to the Boss Open.
T&Cs apply | 18+
Table of contents
Lorenzo Musetti sold himself at a high price and flexed his muscles in the round of 16 when he sent Taylor Fritz (ATP 9), a top 10 player, home with a clean score of 3-0 in just 124 minutes, whereby he did not give up a single service game with 84 percent of points won with the first serve and 69 percent with the second. However, he has against Djoker Lost nine of the ten duels so far – including both meetings in 2025. In particular, at the Miami Masters, the Serb overcame the Italian with a 2-0 victory (6:2 and 6:2). We don’t trust the 23-year-old to win more than one set, which is why we put a handicap of -1.5 sets on the exceptional Serbian player in our tip.
Lorenzo Musetti – Novak Djokovic
Odds | 3 top tips
It is certainly conceivable that the fifth in the world rankings from Tuscany will once again serve excellently and make life difficult for Djoker, especially in the first sentences. However, Nole always started the games excellently throughout the tournament On the way to the quarter-finals, they never lost more than three games in the first set. A very harmonious alternative is the tip that the 38-year-old Serb will also win the first set against the Italian.
The ODDSET app has odds of 1.53 for Lorenzo Musetti against Novak Djokovic. Please also note the possibility of winning an ODDSET free bet without making a deposit, which can also be used to replay much riskier tips without having to make any personal investment.
Statistics highlights for
Lorenzo Musetti gegen Novak Djokovic 

Lorenzo Musetti – Novak Djokovic Direct comparison / H2H balance
Head to head: 1:9
There have already been ten meetings between the two players and with nine wins, Novak Djokovic is clearly ahead in direct comparison. Only at the Monte-Carlo Rolex Masters 2023 did the Serbian Lorenzo Musetti once have to admit defeat 1:2 (6:4, 5:7 and 4:6) in a close match over 32 games. Since then, six games in a row have gone to the 24-time Grand Slam champion – including both meetings in the 2025 season.
Betting base forecast &
Lorenzo Musetti – Novak Djokovic
Tipp
All in all, our prediction for Lorenzo Musetti against Novak Djokovic is clearly aimed at the Serbian’s progress. Although the Italian is now number five in the world, he achieved his greatest successes on clay courts and has so far only impressed on hard courts at the US Open 2025, where he was able to reach a Grand Slam quarter-final on this surface for the first time. The 23-year-old came Down Under In his first four participations in the men’s singles, he only won a total of three singles games – a yield that he has already more than doubled with four wins on the way to this year’s quarter-finals.
Key Facts –
Lorenzo Musetti vs. Novak Djokovic
Tipp
- Novak Djokovic is 9-1 ahead against Lorenzo Musetti H2H
- Lorenzo Musetti has already won 4 Australian Open games in 2026 – 1 more than in his 4 previous participations
- Novak Djokovic won 102 of his 112 Australian Open games
The young Italian certainly has the potential to annoy Djoker. However, we don’t trust the player from Tuscany to win more than one set. Accordingly, it makes sense to put a handicap of -1.5 sets on the Serbian superstar, who was given three days to regenerate after his victory in the third round thanks to the bye in the round of 16.
For Djoker to win either 3:1 or 3:0, Lorenzo Musetti against Novak Djokovic has betting odds of 1.65 available at Interwetten. If you are not yet registered with this bookmaker, you can currently win a 100% deposit bonus of up to €100 as well as an exclusive €10 free bet without a deposit with the Interwetten new customer bonus.

Lorenzo Musetti vs. Novak Djokovic
– best odds Australian Open
Total sets:
Three sets: 2.50 @bet365
Four sets: 2.60 @bet365
Five sets: 3.40 @bet365
At least 1 tiebreak in the match?
AND: 1.63 @bet365
NO: 2.10 @bet365
Betting odds as of January 27, 2026, 8:59 a.m