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‘Monday Night Football’ prediction, odds, spread, time: 49ers vs. Colts Expert Picks in Race 18-4
The Indianapolis Colts will look to snap a four-game losing streak when they face the San Francisco 49ers on Monday Night Football. San Francisco is coming off a 37-24 win over the Tennessee Titans on Sunday, while Indianapolis dropped an 18-16 decision at Seattle. The 49ers (10-4), who are in third place in the NFC West, are 6-2 on the road this year. The Colts (8-6), third in the AFC South, are 6-1 at home. Indianapolis will start 44-year-old Philip Rivers for the second week in a row. Kickoff at Lucas Oil Stadium in Indianapolis is scheduled for 8:15 p.m. ET. The Colts lead the all-time series 27-19, including wins in each of the last five meetings. San Francisco is a 4.5-point favorite in the latest 49ers vs. Texas odds. Colts, while the over/under for total points scored is 46 at DraftKings Sportsbook. 49ers, be sure to check out SportsLine NFL expert Micah Roberts’ ‘Monday Night Football’ predictions. New users can target the DraftKings promo code, which offers $200 in bonus bets if your bet wins to bet on props like Christian McCaffrey, TD’s all-time leading scorer: Roberts has worked in the Las Vegas sports betting industry for more than 20 years, including a 13-year tenure as director of books for Station Casinos. Armed with an elaborate network of sources, Roberts has unparalleled information across multiple sports. Most importantly, Roberts reads the 49ers’ pulse. He is 18-4 (+1360) in his last 22 picks against the spread in games involving San Francisco. Anyone who followed could have seen great returns. Now, Roberts has his sights set on the 49ers vs. Colts and just made his picks and predictions. You can head over to SportsLine now to see their picks. Here are several NFL odds and NFL betting lines for Colts vs. Colts. 49ers: 49ers vs. Colts spreadSan Francisco -4.5 at DraftKings Sportsbook49ers vs. 49ers can win Quarterback Brock Purdy has played in six games this season. He completed 67.9% of his passes for 1,442 yards and 12 touchdowns, with seven interceptions and a 96.0 rating. In the win over Tennessee, he completed 23 of 30 passes for 295 yards and three touchdowns. He completed 22 of 38 passes for 309 yards and two touchdowns with two interceptions in a 26–21 loss to Jacksonville on September 28. Running back Christian McCaffrey continues to put up huge numbers. He leads the 49ers in both rushing and receiving. In 14 games, he rushed 259 times for 922 yards (3.6 average) and nine touchdowns. He also has 86 receptions for 820 yards (9.5 average) and five touchdowns. In a 41-22 win over Arizona on Nov. 16, he carried 13 times for 81 yards and two touchdowns, while catching five passes for 40 yards and a score. See which team to bet on SportsLine. Bet on Brock Purdy to surpass 247.5 passing yards on DraftKings: Why the Colts can win Running back Jonathan Taylor has been dominant and leads the Indianapolis offense. In 14 games, he carried 272 times for 1,443 yards (5.3 average) and 16 touchdowns. He also has 38 receptions for 318 yards and two touchdowns. In a 31–25 overtime victory over the Atlanta Falcons on November 9, he carried 32 times for 244 yards and three touchdowns. Wide receiver Michael Pittman Jr. In 14 games, he had 72 receptions for 725 yards (10.1 average) and seven touchdowns. He has five explosive plays of 20 yards or more, including a long of 27, with 245 yards after the catch and 44 first-down conversions. In a 36-19 loss at Jacksonville, he caught nine passes for 79 yards, including a long of 24. See which team to bet on at SportsLine. Bet on Jonathan Taylor to go over 16.5 for the longest run on DraftKings: How to make 49ers vs. 49ers picks. ColtsRoberts analyzed 49ers vs. He also discovered a critical X-factor that makes him jump to one side of the spread. He’s just sharing what it is, and which side to bet on, on SportsLine. Who beats the 49ers against the Colts, and what critical X-factor makes a spread side must-win? Visit SportsLine now to see which side of the 49ers vs. Colts you need to jump, all from the expert who is 18-4 in his last 22 San Francisco 49ers picks and find out.
Published: 2025-12-22 23:45:00
source: www.cbssports.com
