Mitchell Pearce and Kalyn Ponga have been in shape for the past few weeks, but they play the leading role when Newcastle rages over a slow team in South Sydney.
Enari Tuala and then Kurt Mann each tried to burn the rabbits within the first 15 minutes.
Ponga later extended the lead in half with a single-handed move, zigzagged, and struggled through several defenders to find the line.
Both the Knights and the Rabbitohs want to prove that they should be real contenders for the title this season.
The Knights looked chunky last week when they narrowly lost to Parramatta.
Bunnies coach Wayne Bennett trains his 850th game.
MATCH CENTER: Rabbitohs vs. Knights updates, video, SuperCoach Score
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