It kicks off at 12:30 CET (11:30 GMT) at the Stadio Meazza in San Siro, Milan.
MILAN, ITALY – NOVEMBER 29: Gustav Isaksen of SS Lazio compete for the ball with Strahinja Pavlovic of AC Milan during the Serie A match between AC Milan and SS Lazio at Giuseppe Meazza Stadium on November 29, 2025 in Milan, Italy. (Photo by Marco Rosi – SS Lazio/Getty Images)
Sassuolo have travelled to San Siro without the injured Romagna, Skjellerup, Pieragnolo, Turati, Berardi and Boloca and their coach Fabio Grosso, a 2006 Italy World Cup winner, is serving a one-game ban.
MILAN, ITALY – NOVEMBER 29: Ruben Loftus-Cheek of AC Milan in action during the Serie A match between AC Milan and SS Lazio at Giuseppe Meazza Stadium on November 29, 2025 in Milan, Italy. (Photo by Marco Luzzani/Getty Images)
Pulisic and Nkunku will start up front for Milan. Ruben Loftus-Cheek gets the nod in the middle of the park, pushing Samuele Ricci to the bench.
Cristian Volpato replaces the injured Berardi for Sassuolo.
Milan (3-5-2) Maignan; Tomori, Gabbia, Pavlović; Saelemaekers, Loftus-Cheek, Modric, Rabiot, Bartesaghi; Nkunku, Pulisic.
Milan bench: Pittarella, Terracciano; Athekame, De Winter, Estupiñan, Odogu; Jashari, Ricci.
Sassuolo (4-3-3): Murić; Walukiewicz, Idzes, Muhamerović, Candé; Thorstvedt, Matić, Koné; Volpato, Pinamonti, Fadera.
Sassuolo bench: Satalino, Zacchi; Coulibaly, Doig, Odenthal; Iannoni, Lipani, Vranckx; Cheddira, Laurientié, Moro, Pierini.
