The Detroit Lions and Buffalo Bills open Week 2 of the NFL season on Thursday Night Football, meeting on September 17, 2026, at 8:15 p.m. ET (5:15 p.m. PT) at the new Highmark Stadium in Orchard Park, New York.
Highmark Stadium Debut Hosts Week 2 Opener
Thursday night marks the first regular-season game at the Bills’ newly constructed Highmark Stadium. Both teams enter the matchup carrying 1-0 records. The Bills secured a Week 1 victory over the Houston Texans, a game where quarterback Josh Allen tossed two touchdown passes and the defense forced a late turnover to seal the win. Meanwhile, the Lions survived a narrow contest against the New Orleans Saints, prevailing in overtime following a 156-yard rushing performance from Jahmyr Gibbs.
Streaming and Broadcast Information
Prime Video holds the exclusive live-streaming rights for Thursday Night Football. Subscribers can watch the broadcast live on Amazon’s platform, while fans located in the participating teams’ local television markets can access the game for free via local over-the-air broadcasts. Additional streaming options include Amazon’s Twitch channel, which will carry the Prime Video feed, and NFL+ for mobile device users.
Al Michaels returns to handle play-by-play duties alongside analyst Kirk Herbstreit, with Kaylee Hartung providing reports from the sideline. The pregame, halftime, and postgame desk features host Charissa Thompson joined by former NFL players Tony Gonzalez, Richard Sherman, Ryan Fitzpatrick, and Andrew Whitworth. Additional coverage includes feature segments from Taylor Rooks, league updates from reporter James Palmer, and recurring appearances by Marshawn Lynch. Prime Video also provides a Spanish-language broadcast, TNF en Español, featuring announcer Miguel Gurwitz and analyst Rolando Cantú.
Next Steps on the Road to Super Bowl LXI
Both franchises continue their early-season campaigns aimed at positioning themselves for the 2027 playoffs and a run toward Super Bowl LXI. Following Thursday’s clash, the teams will return to their respective practice facilities to prepare for their Week 3 opponents. Football fans can follow further league developments and official injury reports through the NFL’s official communications channels.
