St. Louis Cardinals vs. Seattle Mariners: MLB Betting Odds, Preview & Analysis for April 25, 2026
St. Louis Cardinals and Seattle Mariners face off at Busch Stadium on Saturday, April 25, 2026, with first pitch scheduled for 2:15 p.m. ET. The Cardinals enter as home underdogs at +124 against the Mariners, who are favored at -148 on the moneyline, according to verified betting odds from multiple sportsbooks. This matchup follows the Mariners’ 3-2 victory over the Cardinals in the previous day’s game.
Game Details and Betting Lines
The St. Louis Cardinals (14-11) host the Seattle Mariners (12-15) in the second game of their series at Busch Stadium. Matthew Liberatore (0-1) is set to start for St. Louis, while Bryan Woo (1-2) takes the mound for Seattle. The over/under for total runs is set at 8.0.
Betting odds across verified sources reveal consistency: the Mariners are favored at approximately -148 (implying a 59.7% win probability), while the Cardinals are underdogs at +124. These lines reflect the Mariners’ slight edge despite the Cardinals’ home-field advantage and better overall record (14-11 vs. 12-15).
Recent Performance and Trends
Seattle has won seven of its 12 games when favored by at least -148 on the moneyline this season, converting at a 58.3% rate. The Mariners have entered games as favorites 23 times in 2026, winning 11 of those contests (47.8%). In games with a posted spread, Seattle holds an ATS record of 9-18-0.
St. Louis has shown resilience at home, though specific home/away splits for the Cardinals were not detailed in the verified sources. Both teams have participated in 27 games this season, with the Mariners and their opponents hitting the over in 12 of those matchups.
Starting Pitchers Analysis
Bryan Woo enters the matchup with a 1-2 record for the Seattle Mariners. In his most recent start against St. Louis on April 24, Woo pitched 6.0 innings, allowing 2 runs on 5 hits with 2 strikeouts, earning the win in Seattle’s 3-2 victory.
Matthew Liberatore (0-1) starts for the Cardinals after taking the loss in Friday’s game, where he pitched 5.1 innings, allowing 3 runs on 4 hits with 8 strikeouts. Liberatore’s strikeout ability presents a potential advantage despite his 0-1 record.
Key Offensive Contributors
Josh Naylor provided offensive leadership for Seattle in the previous game, going 1-for-3 with a home run and an RBI. His power surge in the series opener highlights his importance to the Mariners’ lineup.
Andre Pallante was credited with the loss for St. Louis in Friday’s game after pitching 5.1 innings, allowing 3 runs on 4 hits with 8 strikeouts. While Pallante relieved Liberatore in that contest, the Cardinals’ starting rotation depth remains a factor for Saturday’s game.
Where to Watch and Follow
The game will be televised locally on Cardinals.TV and Mariners.TV, with live streaming options available through each team’s official platforms. National broadcast details were not specified in the verified sources, but local coverage ensures accessibility for fans in both markets.
Betting Trends and Considerations
Sports betting trends indicate the Mariners have covered the spread in 9 of 27 games this season, while failing to cover in 18 games. The over has hit in 12 of 27 games involving Seattle this year, suggesting a tendency toward lower-scoring contests when involving the Mariners.
For the Cardinals, specific betting trends were not detailed in the verified sources beyond their underdog status in this matchup. Bettors should consider Liberatore’s strikeout potential and Woo’s recent success against St. Louis when evaluating the pitching matchup.
What’s Next
Following this Saturday afternoon contest, both teams will continue their respective schedules with the Mariners preparing for upcoming road games and the Cardinals hosting subsequent series at Busch Stadium. The next scheduled action for both clubs is their next regular-season game, with exact dates and opponents to be determined by the MLB schedule.
For real-time updates, official team websites and MLB.com provide the most accurate information regarding lineup changes, weather delays, or other game-day developments.
As always, responsible betting practices are encouraged, with individuals advised to wager only within their means and to consult official sportsbook terms and conditions before placing any wagers.
