It kicks off at 20:45 CET (19:45 GMT) at the Stadio Meazza in San Siro in Milan.
Santiago Gimenez is unavailable for the Rossoneri, while Lecce must cope without the suspended Kialonda Gaspar and Danilo Veiga and the injured Medon Berisha and Francesco Camarda.
MILAN, ITALY – DECEMBER 28: Christian Pulisic of AC Milan celebrates after scoring their team’s first goal during the Serie A match between AC Milan and Hellas Verona FC at Giuseppe Meazza Stadium on December 28, 2025 in Milan, Italy. (Photo by Marco Luzzani/Getty Images)
Leao and Pulisic are expected to start up front, according to Sky and Gazzetta.
MILAN, ITALY – JANUARY 08: Rafael Leao of AC Milan celebrates scoring his team’s first goal during the Serie A match between AC Milan and Genoa CFC at Giuseppe Meazza Stadium on January 08, 2026 in Milan, Italy. (Photo by Marco Luzzani/Getty Images)
Strahinja Pavlović is available, but unlikely to feature in the Milan XI after suffering a head injury last week.
Lecce will look to Nikola Štulić up front. Tete Morente and Santiago Pierotti compete for a starting spot on the right wing, while Lameck Banda returns to Lecce’s starting XI after serving a one-game ban in the previous round.
The match will be broadcast live on TNT Sports 1 and DAZN in the UK and Ireland and on Paramount+ in the USA. Football Italia will provide a live commentary via a live blog.
Milan (3-5-2): Maignan; Tomorry, Gabbia, Of Winter; Salemakekers, Modric, Rabiot, Stupling; Pulisic, Leao.
Lecce (4-2-3-1): Falcon; Perez, Siebert, Tiago Gabriel, Gallo; Coulibaly, Ramadani; Pierotti, Gandelman, Banda; Stulic.
