Former Cavaliers in Major League Baseball
| Years at UVA | Organization (Level) | Bio | |
| Andrew Abbott | 2018-21 | Cincinnati Reds (MLB) | MLB | UVA |
| Ernie Clement | 2015-17 | Toronto Blue Jays (MLB) | MLB | UVA |
| Connelly Early | 2023 | Boston Red Sox (MLB) | MLB | UVA |
| Zack Gelof | 2019-21 | Athletics (MLB) | MLB | UVA |
| Daniel Lynch IV | 2016-18 | Kansas City Royals (MLB) | MLB | UVA |
| Jake McCarthy | 2016-18 | Arizona Diamondbacks (MLB) | MLB | UVA |
| Josh Sborz | 2013-15 | Texas Rangers (MLB) | MLB | UVA |
| Bennett Sousa | 2015-18 | Houston Astros (MLB) | MLB | UVA |
| Pavin Smith | 2015-17 | Arizona Diamondbacks (MLB) | MLB | UVA |
| Chris Taylor | 2010-12 | Los Angeles Angels (MLB) | MLB | UVA |
| Kyle Teel | 2021-23 | Chicago White Sox (MLB) | MLB | UVA |
| Mike Vasil | 2019-21 | Chicago White Sox (MLB) | MLB | UVA |
Former Cavaliers in Minor League Baseball
| Years at UVA | Organization (Level) | Bio | |
| Ethan Anderson | 2022-24 | Baltimore Orioles (High-A) | MiLB | UVA |
| Chris Arroyo | 2025 | Miami Marlins (A) | MiLB | UVA |
| Jake Berry | 2021-23 | Cleveland Guardians (A) | MiLB | UVA |
| Brian Edgington | 2023 | Cincinnati Reds (High-A) | MiLB | UVA |
| Jake Gelof | 2021-23 | Los Angeles Dodgers (High-A) | MiLB | UVA |
| Henry Godbout | 2023-25 | Boston Red Sox (High-A) | MiLB | UVA |
| Luke Hanson | 2023-25 | Texas Rangers (A) | MiLB | UVA |
| Nic Kent | 2019-21 | Colorado Rockies (AA) | MiLB | UVA |
| Caleb Knight | 2017-18 | Chicago Cubs (AAA) | MiLB | UVA |
| Griff McGarry | 2018-21 | Philadelphia Phillies (AA) | MiLB | UVA |
| Zach Messinger | 2019-21 | New York Yankees (AAA) | MiLB | UVA |
| Noah Murdock | 2017-19 | Kansas City Royals (AAA) | MiLB | UVA |
| Brandon Neeck | 2019-22 | Los Angeles Dodgers (AA) | MiLB | UVA |
| Chris Newell | 2020-22 | Los Angeles Dodgers (AA) | MiLB | UVA |
| Ethan O’Donnell | 2023 | Cincinnati Reds (AA) | MiLB | UVA |
| Griff O’Ferrall | 2022-24 | Baltimore Orioles (High-A) | MiLB | UVA |
| Devin Ortiz | 2018-22 | San Diego Padres (AA) | MiLB | UVA |
| Nate Savino | 2020-22 | Arizona Diamondbacks (AA) | MiLB | UVA |
| Casey Saucke | 2022-24 | Chicago White Sox (A) | MiLB | UVA |
| Anthony Stephan | 2022-24 | Cincinnati Reds (High-A) | MiLB | UVA |
| Matt Thaiss | 2014-16 | Tampa Bay Rays (AAA) | MiLB | UVA |
| Andy Weber | 2016-18 | Arizona Diamondbacks (AAA) | MiLB | UVA |
| Kyle Whitten | 2018-21 | Tampa Bay Rays (AAA) | MiLB | UVA |
*As of September 10, 2025
