Gennaro Gattuso could make his Italy debut against Estonia with a 4-2-3-1 formation, including Mateo Retegui, Moise Kean, Sandro Tonali and Riccardo Calafiori.
It kicks off at the Stadio di Bergamo on Friday at 19.45 UK time (18.45 GMT).
This is the third game for the Azzurri in the 2026 World Cup qualifying campaign, after the 3-0 defeat in Norway and 2-0 win over Moldova.
Those were both under Luciano Spalletti, who was sacked in June and replaced by Gattuso.
Reggio Nello Emilia – June 9: Sandro Tonali During the Fifa 2026 Qualifier Bethaeen Italy and Moldova at Mapei Stadium – Tricolor City on June 09, 2025 in Reggio Nel Emilia, Italy. (Photo by Alessandro Sabattini/Getty Images)
Those are relatively locked downalong with Tonali and Nicolò Barella in midfield, but the attack is what remains to be seen.
Both Retegui and Kean can be used together in a 4-2-3-1, a 4-3-3, or a 4-4-2 formation.
Atalanta striker Gianluca Scamacca was forced to withdraw due to a knee issue, so will not be playing in his home stadium.
epa11976939 Germany’s forward Jonathan Burkardt (R) kicks the ball against Riccardo Calafiori during the UEFA Nations League quarterfinals first leg soccer match between Italy and Germany at the Giuseppe Meazza Stadium in Milan, 20 March 2025. EPA-EFE/Daniel Dal Zennaro
Italy vs. Estonia probable line-up (4-2-3-1): Donnarumma; Di Lorenzo, Calafiori, Bastoni, Dimarco; Barella, Tonali; Politano, Kean, Zaccagni; Stagger