Thirteen matchups fill the National Football League slate, following the Thursday night opener between the Chicago Bears and New England Patriots. Four franchises—the Buffalo Bills, Jacksonville Jaguars, Los Angeles Chargers, and Washington Commanders—sit out this weekend on their scheduled bye weeks, leaving twenty-six teams to contest the remaining fixtures across Sunday, Monday, and Tuesday.
Pittsburgh Steelers Face New Orleans Saints at Paris Venue
The Pittsburgh Steelers carry a 4-2 record into an overseas matchup against the 2-4 New Orleans Saints on Sunday, Oct. 25, at 2:30 p.m. local time in Paris. Pittsburgh operates without wide receiver Michael Pittman in the passing game, while running back Jaylen Warren shoulders the rushing workload should Rico Dowdle remain sidelined. New Orleans counters with quarterback Tyler Shough directing a passing attack featuring targets Chris Olave, Devaugn Vele, and Juwan Johnson alongside running back Alvin Kamara. Both defenses enter the contest allowing minimal production through the air.
San Francisco 49ers Visit Atlanta Falcons
Unbeaten at 6-0, the San Francisco 49ers travel to face the 2-4 Atlanta Falcons on Sunday, Oct. 25, at 6:00 p.m. Eastern. San Francisco deploys an offensive line designed to shield quarterback Brock Purdy, anchoring a balanced scheme against an Atlanta defense. The Falcons rely on an established ground game to offset their early-season record.
Cincinnati Bengals Meet Baltimore Ravens in AFC North Clash
Division rivals Cincinnati Bengals (3-2) and Baltimore Ravens (4-2) collide on Sunday, Oct. 25, at 6:00 p.m. Baltimore lists uncertainty around the availability of quarterback Lamar Jackson and wide receiver Rashad Bateman. The Bengals project to feature a pass-heavy approach, while the Ravens lean on running back Derrick Henry.
Carolina Panthers Host Tampa Bay Buccaneers
The 3-2 Carolina Panthers welcome the 1-5 Tampa Bay Buccaneers on Sunday, Oct. 25, at 6:00 p.m. Carolina quarterback Bryce Young anchors a pass-oriented offense complemented by running back Chubby Hubbard, who averages 4.7 yards per carry. Tampa Bay anticipates the return of quarterback Baker Mayfield alongside running back Bucky Irving.
New York Giants Travel to Face Houston Texans
Holding a 3-2-1 standing, the New York Giants visit the 2-4 Houston Texans on Sunday, Oct. 25, at 6:00 p.m. Eastern. New York hands the starting quarterback duties to J.J. McCarthy, while running back Cam Skatteebo looks to establish form. Houston enters after securing consecutive victories behind a defensive unit that held firm following an 0-4 start.
Indianapolis Colts Challenge Undefeated Minnesota Vikings
The 2-4 Indianapolis Colts visit the undefeated 5-0 Minnesota Vikings on Sunday, Oct. 25, at 6:00 p.m. Eastern. Minnesota features a defensive front coordinated around veteran linebacker Andrew van Ginkel, presenting a challenging assignment for Colts running back Jonathan Taylor.
Miami Dolphins Play New York Jets in AFC East Battle
Winless at 0-5, the Miami Dolphins square off against the 2-4 New York Jets on Sunday, Oct. 25, at 6:00 p.m. Eastern. Both franchises occupy the bottom tier of the division as New York seeks separation and Miami targets its initial victory of the campaign.
Cleveland Browns Travel to Tennessee Titans
The 4-2 Cleveland Browns face the 1-5 Tennessee Titans on Sunday, Oct. 25, at 6:00 p.m. Eastern. Cleveland features quarterback Deshaun Watson, who directed a comeback victory against Baltimore by shutting down opposing possessions, while Tennessee looks to build on its first win.
Denver Broncos Play Arizona Cardinals
Denver enters at 4-2 to play the 2-4 Arizona Cardinals on Sunday, Oct. 25, at 9:05 p.m. Eastern. Arizona secured a narrow victory behind a ground-heavy attack and an aggressive defense, setting up a test against a Broncos defense.
Green Bay Packers Meet Detroit Lions in NFC North Showdown
The 4-2 Green Bay Packers carry a three-game winning streak into a matchup against the 3-2 Detroit Lions on Sunday, Oct. 25, at 9:25 p.m. Eastern.
Los Angeles Rams Battle Las Vegas Raiders
The 2-4 Los Angeles Rams meet the 3-3 Las Vegas Raiders on Sunday, Oct. 25, at 9:25 p.m. Eastern. Las Vegas deploys quarterback Kirk Cousins behind an offensive line and utilizes running back Ashton Jeanty, while Los Angeles counters with wide receivers Puka Nacua and Davante Adams.

Kansas City Chiefs Visit Seattle Seahawks on Monday Night
The 5-0 Kansas City Chiefs travel to play the Seattle Seahawks (3-3) on Monday, Oct. 26, at 1:20 a.m. Eastern. Kansas City adds running back Kenneth Walker to strengthen its rushing attack. Seattle deploys quarterback Sam Darnold, protected by his offensive line, to target wide receiver Jaxon Smith-Njigba downfield against a structured Chiefs defense.
Dallas Cowboys Face Philadelphia Eagles in Tuesday Night Finale
Closing out the week, the 2-4 Dallas Cowboys visit the 2-4 Philadelphia Eagles on Tuesday, Oct. 27, at 1:15 a.m. Eastern. Philadelphia operates without quarterback Jalen Hurts, placed on the injured reserve list during a four-game skid, while Dallas attempts to stabilize its roster behind quarterback Dak Prescott.
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