# 1 Alabama and # 2 Clemson are both a big favorite in their respective games on Saturday, but if we've learned anything over the years, it can lead to major upsets later this season. The most important games in the races for the titles ACC, Big Ten, Big 12 and SEC – and of course some college football playoff bids – are over on Saturday as five top-10 teams prevail against either opponent or long-running opponents rivals. There is plenty to digest and to dive all day as the inconvenience will subside. Who will be knocked off? That remains to be seen, but we should find out soon.

Since the action starts early in the day and lasts until late in the evening, let's take a look at Saturday's biggest games and our predictions of what's going to happen in those competitions. Our CBS Sports College football experts have selected each game both directly and against the spread, so you have ample opportunity to decide how to hit a game before the kickoff.

All times east

No. 10 Ohio State (-3.5) at No. 18 Michigan State – Noon on FOX, fuboTV (Try it for free): You'd think Ohio State should not be favored on the road against this Michigan State team, but what if I told you that Ohio State has not lost to Michigan State in East Lansing since 1999? That's right, the Buckeyes won six straight at Spartan Stadium. And while this is an Ohio State team that has a lot of defense concerns, unlike Purdue and Nebraska, I do not think the state of Michigan has a crime that can exploit it. I do not know if the Buckeyes are a "right" game, but I think it's a spread they'll cover. Select: Ohio State -3.5 – Tom Fornelli

# 1 Alabama (-24.5) Mississippi # 16-15: 30hrs on CBS, CBSSports.com: After a weeklong break, at least theoretically, we play again the most popular game in college football: "Will Alabama Cover?" This week the answer is yes. It's one thing for Nick Fitzgerald to look like a complete quarterback against Texas A & M and Louisiana Tech, but it's a whole different thing to do against the Crimson Tide. The defensive line will slow down the run with just four, the defense will dominate in the passing game and Tua Tagovailoa will have another Heisman-worthy game in a big home win. Choose: Alabama -24.5 – Barrett Sallee

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Oklahoma State at # 6 Oklahoma (-17.5) – 3:30 pm on ABC: The state of Oklahoma has already shown that he can play for a match when the situation requires, but can he do it twice? Things went well in beating Texas but the Cowboys must play their best game – and their best defense – of the season to play with Oklahoma. Choose: Oklahoma -17.5 – Ben Kercheval

No. 24 Auburn in No. 5 Georgia (-14) – 7:00 pm on ESPN: You can never predict exactly what will happen in rivalry games, but I'm pretty confident in what this game will look like. The Bulldogs will top Auburn's lazy attack and force Jarrett Stidham into a dodgy situation against a hard pass defense. But Stidham has improved in the last few games and will be successful enough to make the Bulldogs sweat. Swift, Elijah Holyfield and the rest of the attack will wear down the tigers and retreat in the fourth quarter to win – but no cover. Pick: Auburn +14 – Barrett Sallee

# 2 Clemson (-20) at Boston College # 5 – 8pm on ABC: There are too many subjective ways of talking about the "best" Clemson team of all time, without a few arguments from those who have lived in the glories of the Frank Howard years, but I think this is the most dominant Clemson team We've already seen it like its playoff rival Alabama, you can not set a distribution that I do not want to complete with the tigers. Select: Clemson -20 – Chip Patterson


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