The league did not immediately release a new game date for the Guardians, who until last year were called the Cleveland Indians.
The move came hours after the Guardians announced that 63-year-old manager Terry Francona had tested positive for covid-19 and that, despite being asymptomatic, he would be sidelined for a indefinite period.
Francona, a two-time World Series champion with the Boston Red Sox, has missed games the past two seasons due to various gastrointestinal, hip and foot issues.
The 2022 Major League Baseball season kicked off a month ago with a one-week delay due to the labor dispute between owners and players.
Last year the competition postponed nine of its more than 2,400 games due to the pandemic.