The first legs will be played on Thursday 17 February, the return matches will be played a week later on 24 February.
The seed heads – the numbers 2 from the group stage of the Europa League – first play on the move. Clubs from the same country avoid each other in this phase.
Whoever loses, is exhausted in Europe. The winners of these play-offs meet the winners of the groups in the Europa League in the 1/8th finals.
The group winners: Lyon (Fra), Monaco (Fra), Spartak Moscow (Russian), Eintracht Frankfurt (Ger), Galatasaray (Tur), Red Star (Ser), Leverkusen (Ger) and West Ham (Eng).