Lianne Tan, 38th in the world, lost in straight sets (21-11, 21-17) in 42 minutes against the Indonesian Gregoria Mariska Tunjung, 23rd in the world and 14th seed.
Lianne Tan won her first Group M match on Tuesday against Burmese Thuzar Thet Htar, 65th in the world, 2 sets to 0 (21-6, 21-8) in 28 minutes. But only the first of each of the 14 groups qualifies for the knockout stages.
Lianne Tan, 30, was playing her third Games. The Belgian champion was eliminated in the group stage in 2012 in London and four years later in Rio.