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Manchester United midfielder Eric Bailly is “very close” to a return, but he is not expected to play in the resumption of the English Cup third round against the Wolves.
Bailly, 25, has had two knee injuries that have kept him out of competitive action since April, but UK boss Ole Gunnar Solskjaer said he “could be coming back for the weekend” against Liverpool.
Ashley Young, tied to a move at Inter, will also not play.
Wolves are without Diogo Jota, Bruno Jordao and Wily Boly on Wednesday.
Striker Jota has a dead leg, midfielder Jordao is out due to an ankle injury, while central defender Boly is still recovering from an ankle fracture sustained in a training session in October.
The winners will play in Premier League Watford or League One Tranmere.
The Hornets were 3-0 in the first game, but Tranmere scored three goals in the second half to force a replay, which was scheduled for Tuesday but was postponed due to a sodden shot.
This game is the 38th in the wolf season after they started their Europa League qualifying campaign in July and boss Nuno Espirito Santo was delighted with how his team handled the extra workload.
“It’s about how they prepare daily with how they recover and compete, about all players,” he said.
“It’s the most important game, the next one is always the most important.”
United, like the Wolves, is also in the last 32 of the Europa League, and will play for the 14th time in 46 days.
“It’s relentless,” said United Ole chief Gunnar Solskjaer. “We still have five or six games before the winter break, 18 games in less than 60 days that are physically and mentally demanding, we have to excite them.
“This tournament is one of those that we all dream of winning when we are young. I loved my time in the finals and lifting the trophy, so we want to pass.”
The original Molineux game ended 0-0 as United failed to kick in the goal – the first time it had happened since January 2015, although both sides hit the wood in the second half.
- Manchester United are winless in five games against the Wolves in all competitions (drawn three, lost two) after a 5-0 win in the Premier League in March 2012.
- The wolves are winless in their last 10 competitive trips to face Manchester United at Old Trafford (drawn two, lost eight) since the February 1980 1-0 win.
- Manchester United were brought to the English Cup third round for the first time since 2012-13, when they knocked out West Ham at Old Trafford.
- The wolves lost nine of their previous 10 FA Cup third round replays, winning the other against Oldham in 2007.
- The wolf diogo Jota has found the back of the net in two of his last three appearances against Manchester United, although both goals have gone to Molineux.