Scores were closed on 20-holes in the last minute on Wednesday, when Blake Ferguson was on the sidelines and when Tedesco found his second try of the night.
It came after Queensland forward Josh Papalii crossed in the 77th minute and debutant Ethan Lowe nailed a pressure conversion to level the game.
The dramatic finish ended a series of seven consecutive defeats in Origin deciders for the Blues, dating back to the beginning of the Maroons dynasty in 2006.
It is also Mitchell Pearce & # 39; s first series win over Queensland in eight attempts.
NSW seemed on its way to a comfortable finish when Tedesco and Damien Cook broke a 9-tie with attempts in nine minutes.
The horror of series over, however, seemed to return after Queensland scored twice through Josh McGuire and Papalii in the last eight minutes.
When the conversion of Lowe continued, Origin seemed ready for the first gold point competition for a sold-out 82,565 crowd at the ANZ Stadium in Australia.
But Tedesco, who ended the evening with a game high of 222 meters and approached 10 busts, changed the hero with his winning four-point.
Tedesco, player of the series, turned the game three times, starting with a 65-meter kick back in the 34th minute to set up the first attempt of the Blues.
It was after the strong start of the Maroons that debutant Corey Norman changed points, forced a line loss and then went to Felise Kaufusi to score.
More pressure from Maroons resulted in a penalty goal – one of the 12 offenses decided by the referees in a frustrating stop-start match.
However, Tedesco's kickback set Paul Vaughan to equal the game at rest, before producing his second half of the heroism.